| Product Name | PACT Antibody (H-67) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 73-139 mapping within an internal region of PACT of human origin |
| Modification Notes | Interferon-inducible double stranded RNA-dependent protein kinase activator, also designated PKR-associated protein X (RAX) or PACT, acts as a protein activator of PKR. Following stress such as serum starvation or peroxide or arsenite treatment, PACT associates with and activates PKR, resulting in eIF2? activation (phosphorylation), consequent translation inhibition and apoptosis. PACT can directly interact with double stranded RNA (dsRNA), however, eIF2? activation occurs only in the absence of dsRNA. The presence of certain growth factors may suppress the pro-apoptotic function of PACT. In both human and mouse cells, PACT is phosphorylated on Serine 18, and the phosphorylated form activates PKR following stress. PACT may exist as a heterodimer with eIF2?, interacting through its DRBM domain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PACT (protein activator of the interferon-induced protein kinase) of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 73-139 mapping within an internal region of PACT of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 73-139 mapping within an internal region of PACT of human origin |
| Entrez Gene | 8575 |
|---|
| Application Notes | recommended for detection of PACT (protein activator of the interferon-induced protein kinase) of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
