| Product Name | 4.1N Antibody (H-193) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 573-765 mapping within an internal region of 4.1N of human origin |
| Modification Notes | 4.1N protein (band 4.1-like protein 1, neuronal protein 4.1) binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. 4.1 adapter proteins mediate interactions between the cytoskeleton and the overlying plasma membrane. These multiple 4.1N interactions with the cell cytoskelton and plasma membrane may confer stability and plasticity to neuronal membrane. The 4.1N protein is expressed highly in the brain, and is found at lower levels in heart, kidney, pancreas, placenta, lung and skeletal muscle. Four homologous genes (4.1R, 4.1G, 4.1N, and 4.1B) undergo complex alternative splicing. The distribution of these 4.1 spliced gene products along the nephron suggests their involvement in targeting of selected transmembrane proteins in kidney epithelium and, therefore, in regulation of specific kidney functions. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of 4.1N of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 573-765 mapping within an internal region of 4.1N of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 573-765 mapping within an internal region of 4.1N of human origin |
| Entrez Gene | 2036 |
|---|
| Application Notes | recommended for detection of 4.1N of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
