| Product Name | Fox-1 Antibody (H-81) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 38-118 mapping near the N-terminus of Fox-1 of human origin |
| Modification Notes | Fox-1, also known as A2BP, A2BP1 or HRNBP1, is a 397 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one RRM domain. Expressed predominately in muscle and brain tissue, Fox-1 interacts with Ataxin-2 and functions as an RNA-binding protein that regulates alternative splicing events during erythropoiesis, specifically by binding to 5'-UGCAUGU-3' DNA elements. Multiple isoforms of Fox-1 exist due to alternative splicing events. The gene encoding Fox-1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Fox-1 isoforms 1-5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 38-118 mapping near the N-terminus of Fox-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 38-118 mapping near the N-terminus of Fox-1 of human origin |
| Entrez Gene | 54715 |
|---|
| Application Notes | recommended for detection of Fox-1 isoforms 1-5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
