| Product Name | HPA2 Antibody (H-100) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-100 mapping at the N-terminus of heparanse 2a of human origin |
| Modification Notes | Heparanases degrade heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix and play an important role in the extravasation of blood-borne tumor cells and inflammatory leukocytes (1,2). Upon degradation, heparanases free growth factors and cytokines that stimulate cell proliferation and chemotaxis (3,4). Human heparanase 1-3 (HPA1-3) are members of the heparanase family. Three alternative splice variants of the HPA2 transcripts encode predicted intracellular membrane-bound proteins of various lengths (5). HPA2 is expressed in brain, small intestine, prostate, mammary gland, testis, and uterus (5). While HPA2 is not expressed in normal pancreas, it is expressed in pancreatic tumor cell lines MiaPaca-2 and Panc-1 as well as pancreatic adenocarcinoma (5). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of HPA2a, HPA2b, HPA2c of human origin and HPA3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-100 mapping at the N-terminus of heparanse 2a of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-100 mapping at the N-terminus of heparanse 2a of human origin |
| Entrez Gene | 60495 |
|---|
| Application Notes | recommended for detection of HPA2a, HPA2b, HPA2c of human origin and HPA3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
