| Product Name | IL-1RII Antibody (H-71) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 257-327 mapping near the C-terminus of IL-1RII of human origin |
| Modification Notes | Decoy receptors are structurally incapable of activating signaling pathways, but act as anti-inflammatory agents by sequestering agonists for actual signaling complexes. The type II IL-1 receptor (IL-1RII) acts as a decoy receptor for the chemokine interleukin-1 (IL-1). Additionally, the soluble form of IL-1R accessory protein (IL-1R AcP) increases the affinity of binding of IL-1å and IL-1∫ to IL-1RII 100-fold, but does not increase the affinity for another antiinflammatory agent, IL-1R antagonist (IL-1Ra). The end result is a complex regulatory mechanism for IL-1 activated inflammation, whereby dexamethasone and other molecules inducing IL-1RII, function in an immunosupressive and anti-inflammatory manner. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of IL-1RII of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 257-327 mapping near the C-terminus of IL-1RII of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 257-327 mapping near the C-terminus of IL-1RII of human origin |
| Entrez Gene | 7850 |
|---|
| Application Notes | recommended for detection of IL-1RII of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
