| Product Name | Chibby Antibody (M-127) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-127 representing full length Chibby of mouse origin |
| Modification Notes | Chibby, also known as Cytosolic leucine-rich protein or PIGEA-14, is a 126 amino acid highly conserved protein that inhibits ∫-catenin-mediated transcriptional activation by competing with LEF-1 to bind ∫-catenin. Chibby may also play a role in the regulation of the intracellular location of Polycystin-2 and other intracellular proteins. Acting as a homodimer, Chibby is subcellularly localized to the nucleus and golgi apparatus within the trans-golgi network. Interaction with 14-3-3 results in the sequestration of Chibby to the cytoplasm and the formation of a stable complex with ∫-catenin, thereby facilitating nuclear export of ∫-catenin. Though widely expressed, Chibby is found at highest levels in skeletal muscle, heart, placenta and kidney. Down-regulation of Chibby is observed in thyroid and metastatic uterine tumors, suggesting that the gene encoding Chibby may function as a tumor suppressor. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Chibby of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-127 representing full length Chibby of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-127 representing full length Chibby of mouse origin |
| Entrez Gene | 25776 |
|---|
| Application Notes | recommended for detection of Chibby of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
