Application
Western blot analysis of α/β/γ-synuclein expression in mouse brain tissue extract.| Product Name | α/β/γ-synuclein Antibody (FL-140) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The synucleins, including 氓-synuclein (also designated NACP for nonamyloid component precursor), 鈭?synuclein (also designated PNP 14 for phospho-neuroprotein 14) and 漏-synuclein (also designated persyn or BCSG1 for breast cancer-specific gene 1) are presynaptic proteins abundant in neurons. Synucleins are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. 氓-Synuclein, identified as a component of Alzheimer鈥檚 disease amyloid plaques, is localized to neuronal cell bodies and synapses. Coordinate expression of 氓-synuclein and 鈭?synuclein may be important during hematopoetic cell differentiation. A mutant form of 氓-synuclein is found in patients with early onset Parkinson鈥檚 disease. 漏-Synuclein is associated with axonal pathology in Parkinson鈥檚 disease. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of &alpha-synuclein, &beta-synuclein and &gamma-synuclein of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-140 representing full length &alpha -synuclein of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-140 representing full length α-synuclein of human origin |
| Entrez Gene | 6620 |
|---|
Application
Western blot analysis of α/β/γ-synuclein expression in mouse brain tissue extract.| Application Notes | recommended for detection of &alpha-synuclein, &beta-synuclein and &gamma-synuclein of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
