| Modification Notes |
BHLHB4 (basic helix-loop-helix domain containing, class B, 4), also known as BETA4, is a 225 amino acid protein that contains one basic helix-loop-helix (bHLH) domain, a motif that mediates protein dimerization and can bind to the E-box sequence of DNA. Localized to the nucleus, BHLHB4 is thought to function as a transcriptional repressor that may be required for the maintenance of neuronal and pancreatic cells. Addtionally, BHLHB4 may participate in the maturation of rod bipolar cells, suggesting an involvement in retinal development. The gene encoding BHLHB4 maps to human chromosome 20, which houses over 600 genes and comprises nearly 2% of the human genome. |