| Product Name | BCAR3 Antibody (H-47) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | BCAR3 (breast cancer anti-estrogen resistance 3, also designated AND-34 in murine; a novel SH2-containing protein 2 or NSP2, and SH2D3B) overexpression is a characteristic of antiestrogen resistance in human ZR-75-1 breast cancer cells. The deduced 825-amino acid BCAR3 protein contains a Src homology 2 (SH2) domain and shares homology to yeast CDC48. A 3.4-kb BCAR3 transcript is present in heart, placenta, skeletal muscle, spleen, prostate, testis, ovary, small intestine, colon, fetal kidney, and tamoxifen-resistant cancer cell lines. BCAR3 acts as a regulator of R-Ras to mediate the level of insulin receptor substrate 1 (IRS-1) in MCF-7 and ZR-75-1 breast cancer cell lines. BCAR3 also interacts with p130Cas to enhance Src activation and cell migration. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BCAR3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 200-246 mapping within an internal region of BCAR3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 200-246 mapping within an internal region of BCAR3 of human origin |
| Entrez Gene | 8412 |
|---|
| Application Notes | recommended for detection of BCAR3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
