| Modification Notes |
Toll/interleukin-1 receptor/resistance (TIR) adaptor protein (Trif, TICAM-1) can physically bind TIR domains and influence cell signaling. TICAM-1 interacts with TLR3 and mediates dsRNA activation of interferon-beta, through NFkappaB, AP1, or IRF3. Human TICAM-1 maps to chromosome 19p13.3. |