| Modification Notes |
CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENP1), is an integral membrane glycoprotein that acts as an extracellular nucleotide-hydrolyzing enzyme. Characteristically, CD39 and other members of the ecto-ATPase family contain apyrase-conserved regions and function to mediate nucleotide catabolism. CD39L2, also known as ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6), IL6ST2 or IL-6SAG, is a 484 amino acid protein that is similar to CD39 and localizes to the membrane of the golgi apparatus. Expressed ubiquitously with highest expression in heart tissue, CD39L2 is thought to promote glycosylation reactions in the golgi and may catalyze the hydrolysis of extracellular nucleotides. Like other members of the ecto-ATPase family, CD39L2 contains four apyrase-conserved regions and is catalytically activated by calcium and magnesium. Multiple isoforms of CD39L2 exist due to alternative splicing events. |
