Application
Western blot analysis of NTCP expression in Hep G2 whole cell lysate (A) and human liver tissue extract (B).| Product Name | NTCP Antibody (H-42) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 241-282 mapping within an internal region of NTCP of human origin |
| Modification Notes | NTCP (Na(+)/taurocholate transport protein), also known as SLC10A1 (solute carrier family 10 (sodium/bile acid cotransporter family), member 1), is a 349 amino acid multi-pass membrane protein that belongs to the sodium/bile acid symporter family of cotransporters. Localized to the basolateral membranes of hepatocytes, NTCP plays a role in the hepatic sodium/bile acid uptake system, which functions as a substrate-specific, sodium-dependent transporter of both bile and non-bile organic compounds. The gene encoding NTCP maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder å1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NTCP of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 241-282 mapping within an internal region of NTCP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 241-282 mapping within an internal region of NTCP of human origin |
| Entrez Gene | 6554 |
|---|
Application
Western blot analysis of NTCP expression in Hep G2 whole cell lysate (A) and human liver tissue extract (B).| Application Notes | recommended for detection of NTCP of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
