Application
Immunofluores-cence staining of methanol-fixed HeLa cells showing cytoplasmic localization.Application
Western blot analysis of α-synuclein phosphorylation expression in untreated (A) and anisomycin treated (B) C2C12 whole cell lysates.| Product Name | p-α-synuclein Antibody (Tyr 125) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of Tyr 125 phosphorylated α-synuclein of human origin by WB, IP and IF |
| Modification | Phosphoralated |
| Modification Notes | Synucleins are a novel class of GRK substrates. Synucleins (alpha, beta, gamma and synoretin) are highly expressed in brain, but are also found in numerous other tissues. The synuclein family members, including a-synuclein, are speculated to be involved in synaptic regulation and neuronal plasticity. a-synuclein, also designated NACP, PD1, PARK1 and SNCA, is localized to neuronal cell bodies and synapses and has been implicated in the pathogenesis of several neuro-degenerative disorders including Alzheimer’s and Parkinson’s diseases. a-synuclein is phosphorylated on serine residues Ser 129 and Ser 87. In addition, a-synuclein exists in a glycosylated form. The human a-synuclein gene maps to chromosome 4q21. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIF |
| See 1 citations for p-α-synucleinAntibody (Tyr 125): |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of Tyr 125 phosphorylated &alpha -synuclein of human origin by WB IP and IF |
|---|---|
| Tissue Specificity | recommended for detection of Tyr 125 phosphorylated α-synuclein of human origin by WB, IP and IF |
| Entrez Gene | 6622 |
|---|
Application
Immunofluores-cence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
Application
Western blot analysis of α-synuclein phosphorylation expression in untreated (A) and anisomycin treated (B) C2C12 whole cell lysates.| Application Notes | See 1 citations for p-α-synucleinAntibody (Tyr 125): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
