| Product Name | PAF acetylhydrolase Antibody (H-130) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 22-151 mapping near the N-terminus of PAF acetylhydrolase of human origin |
| Modification Notes | The Platelet Activating Factor (PAF) Acetylhydrolases catalyze hydrolysis of the sn-2 ester bond of PAF and related pro-inflammatory phospholipids and thus attenuate their bioactivity. The family of PAF Acetylhydrolases include one secreted plasma isozyme and four intracellular proteins. The intra-cellular isozymes are distinguished by differences in their primary sequence, tissue localization, subunit composition, and substrate preferences. The most thoroughly characterized intracellular isoform, Ib, contains two homologous (63% identity) catalytic subunits (a1 and a2), which harbor all the enzyme’s activity, and a regulatory b subunit. The a subunits readily associate with very high affinity to form homodimers, and this dimerization is essential for both stability and catalytic activity. The b subunit is a product of the LIS1 gene, mutations of which cause Miller-Dieker lissencephaly. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PAF acetylhydrolase of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 22-151 mapping near the N-terminus of PAF acetylhydrolase of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 22-151 mapping near the N-terminus of PAF acetylhydrolase of human origin |
| Entrez Gene | 7941 |
|---|
| Application Notes | recommended for detection of PAF acetylhydrolase of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
