| Product Name | claudin-1/2 Antibody (FL-211) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-211 representing full length claudin-1 of human origin |
| Modification Notes | The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecules. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-1 and Claudin-2 are multi-pass membrane proteins that belong to the claudin family and play an important role in cell-adhesion activity and tight junction-specific events. Defects in the gene encoding claudin-1 are the cause of ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH), an autosomal recessive syndrome characterized by vulgar type ichthyosis, scalp hypotrichosis, scarring alopecia and sclerosing cholangitis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of claudin 1 and 2 and, to a lesser extent claudin 7 and 19 and partially cross-reactive with other claudin family members of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-211 representing full length claudin-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-211 representing full length claudin-1 of human origin |
| Entrez Gene | 9076 |
|---|
| Application Notes | recommended for detection of claudin 1 and 2 and, to a lesser extent claudin 7 and 19 and partially cross-reactive with other claudin family members of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
