Application
Western blot analysis of PARL expression in Jurkat whole cell lysate.| Product Name | PARL Antibody (H-292) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against amino acids 80-371 (Deletion 204-253) mapping near the C-terminus of PARL of human origin |
| Modification Notes | Presenilins associated rhombiod-like protein (PARL) is a mitochondrial intramembrane-cleaving protease belonging to the S54 family of proteins. PARL is involved in intramembrane regulated proteolysis as its catalytic activity involves the cleaving of signaling proteins at intracellular membranes to release active fragments in signal transduction cascades. Using a triad of histidine, serine and asparagine, PARL cleaves type-1 transmembrane domains. PARL is a multi-pass membrane protein localizing to the inner and outer mitochondrial membranes, but it can also be detected in the nucleus following proteolytical processing of P-beta. PARL co-localizes with the presenilins PSEN1 and PSEN2, the familial Alzheimer disease products. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PARL of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against amino acids 80-371 (Deletion 204-253) mapping near the C-terminus of PARL of human origin |
|---|---|
| Tissue Specificity | raised against amino acids 80-371 (Deletion 204-253) mapping near the C-terminus of PARL of human origin |
Application
Western blot analysis of PARL expression in Jurkat whole cell lysate.| Application Notes | recommended for detection of PARL of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
