| Product Name | Rab 33A/B Antibody (H-41) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 35-75 mapping near the N-terminus of Rab 33A of human origin |
| Modification Notes | The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 33B and Rab 33A share conserved effector domains, but share only 55.3% overall amino acid identity. This suggests that Rab 33B and Rab 33A may interact with similar effector and regulatory proteins. Rab 33B is a ubiquitously expressed member of the Rab family of proteins and colocalizes with å-mannosidase II (a Golgi marker) at the medial-Golgi cisternae. Rab 33B is believed to participate in intra-Golgi transport. Rab 33A is predominantly expressed in CD8+ T cells and is involved in tuberculosis (TB) processes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Rab 33A and Rab 33B of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 35-75 mapping near the N-terminus of Rab 33A of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 35-75 mapping near the N-terminus of Rab 33A of human origin |
| Entrez Gene | 9363 |
|---|
| Application Notes | recommended for detection of Rab 33A and Rab 33B of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
