| Product Name | NFRκB Antibody (H-270) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 388-657 mapping within an internal region of NFRκB of human origin |
| Modification Notes | NF˚B (nuclear factor kappa-B) is a ubiquitously expressed transcriptional regulator that, when stimulated, can activate transcription of several genes encoding proteins involved in cell cycle control, cell adhesion and programmed cell death. NFR˚B (nuclear factor related to kappa-B-binding protein), also known as DNA-binding protein R kappa-B, is a nuclear protein that binds to the DNA consensus sequence 5'-GGGGAATCTCC-3' of NF˚B. Binding of NFR˚B is thought to regulate IL-2Rå (interleukin-2 receptor alpha-chain) gene expression, a critical step in T-cell activation. NFR˚B exists as 3 isoforms due to alternative splicing and is expressed primarily in the brain, liver, spleen, testis and thymus NFR˚B gene expression is amplified in acute myeloid leukemia, suggesting a possible role in carcinogenesis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NFRκB of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 388-657 mapping within an internal region of NFR&kappa B of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 388-657 mapping within an internal region of NFRκB of human origin |
| Entrez Gene | 4798 |
|---|
| Application Notes | recommended for detection of NFRκB of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
