| Product Name | Pam Antibody (S-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of Pam of human origin |
| Modification Notes | Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). Pam, also known as MYCBP2 (Myc-binding protein 2), is a 4,640 amino acid nuclear protein that contains one B box-type zinc finger, one DOC domain, one filamin repeat, five RCC1 repeats and one RING-type zinc finger. Expressed ubiquitously with highest expression in thymus and brain, Pam is thought to function as an E3 ubiquitin-protein ligase that may be involved in the degradation of a variety of target proteins. Additionally, Pam may also be involved in regulating c-Myc expression, possibly influencing synaptogenesis. Two isoforms of Pam exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Pam of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with isoforms 1 and 2 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of Pam of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of Pam of human origin |
| Entrez Gene | 23077 |
|---|
| Application Notes | recommended for detection of Pam of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with isoforms 1 and 2 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
