| Modification Notes |
Prostaglandin E Synthase (PGE synthase), also known as PIG12 and MGST1-L1, is a member of protein super family MAPEG, which consists of membrane associated proteins involved in eicosanoid and glutathione metabolism. The expression of this membrane-associated protein can be induced by the proinflammatory cytokine, IL-1b. PGE Synthase is expressed in seminal vesicles, deferent ducts, kidney, heart and spleen. The enzyme activity of PGE Synthase in most organs is glutathione-dependent. PGE Synthase may play a significant role in the progression of Alzheimer’s disease. Human PGE Synthase is localized to chromosome 9q34. |