Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebral cortex tissue showing cytoplasmic and nuclear staining of neuronal and glial cells (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Western blot analysis of X11α expression in mouse brain tissue extract.| Product Name | X11α Antibody (H-265) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-265 mapping at the N-terminus of X11α of human origin |
| Modification Notes | The ∫-Amyloid precursor protein (∫-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The ∫-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular ∫-APP and slowing ∫-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of ∫-APP. Multiple splice varitents of X11 have been identified, including X11å (also designated Mint 1), X11∫ (Mint 2) and X11© (Mint 3). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of X11α of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-265 mapping at the N-terminus of X11&alpha of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-265 mapping at the N-terminus of X11α of human origin |
| Entrez Gene | 320 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebral cortex tissue showing cytoplasmic and nuclear staining of neuronal and glial cells (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Western blot analysis of X11α expression in mouse brain tissue extract.| Application Notes | recommended for detection of X11α of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
