| Product Name | Dapper1 Antibody (H-180) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 281-460 mapping within an internal region of Dapper1 of human origin |
| Modification Notes | Dapper1, also known as DACT1 (dapper, antagonist of beta-catenin, homolog 1), DPR1, HNG3 or FRODO, is an 836 amino acid protein that localizes to both the nucleus and the cytoplasm and contains a C-terminal PDZ-binding motif that is thought to mediate protein-protein interactions. Interacting with Dvl-2, Dapper1 functions to positively regulate Dvl-2-mediated developmental signaling pathways, specifically by preventing the degradation of ∫-catenin, thereby enhancing the transcriptional activation of select genes in the Wnt pathway. Dapper1 is downregulated in hepatocellular carcinoma, suggesting an additional role in tumor suppression. The gene encoding Dapper1 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder å1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Dapper1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 281-460 mapping within an internal region of Dapper1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 281-460 mapping within an internal region of Dapper1 of human origin |
| Entrez Gene | 51339 |
|---|
| Application Notes | recommended for detection of Dapper1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
