| Product Name | BRAP Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 41-340 mapping near the N-terminus of BRAP2of human origin |
| Modification Notes | BRAP (BRCA1 associated protein), also known as RNF52 (RING finger protein 52), BRAP2 or IMP, is a 592 amino acid protein that localizes to the cytoplasm and contains one UBP-type zinc finger and one RING-type zinc finger. Expressed in breast epithelial cells, BRAP functions to negatively regulate MAP kinase activity, specifically by inactivating the Ksr-1 scaffold protein, thereby limiting the formation of Raf/MEK complexes. Additionally, BRAP may play a role in the regulation of nuclear transport and may also act as a Ras-responsive E3 ubiquitin ligase that is subject to auto-ubiquitination. The gene encoding BRAP maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BRAP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 41-340 mapping near the N-terminus of BRAP2of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 41-340 mapping near the N-terminus of BRAP2of human origin |
| Entrez Gene | 8315 |
|---|
| Application Notes | recommended for detection of BRAP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
