| Product Name | SREC-II Antibody (N-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an N-terminal extracellular domain of SREC-II of human origin |
| Modification Notes | SREC-II (scavenger receptor expressed by endothelial cells 2 protein), also known as SCARF2 (scavenger receptor class F, member 2), NSR1 or SREPCR, is an 866 amino acid single-pass type I membrane protein that contains six EGF-like domains. Expressed predominately in endothelial cells found in lung, heart, spleen, placenta, ovary and small intestine, SREC-II is thought to function as an adhesion protein that mediates heterophilic and homophilic interactions via extracellular domains. The gene encoding SREC-II maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of SREC-II of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with SREC: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an N-terminal extracellular domain of SREC-II of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an N-terminal extracellular domain of SREC-II of human origin |
| Entrez Gene | 91179 |
|---|
| Application Notes | recommended for detection of SREC-II of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with SREC: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
