| Product Name | TRMU Antibody (K-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of TRMU of human origin |
| Modification Notes | TRMU (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase), also known as MTO2, MTU1, TRMT, TRMT1 or TRNT1, is a 421 amino acid mitochondrial protein that is evolutionarily conserved and is involved in mitochondrial tRNA modification. Expressed ubiquitously with higher levels of expression in brain, heart, kidney and liver, TRMU functions to catalyze the 2-thiolation of uridine at the wobble position of select tRNA amino acids, including lysine, glutamine and glutamate. This event is required for the formation of 5-taurinomethyl-2-thiouridine, a hypermodified nucleotide that is essential for proper stabilization, aminoacylation and overall function of tRNAs. Polymorphisms in the gene encoding TRMU are thought to aggravate the mitochondrial dysfunction associated with aminoglycoside-induced and non-syndromic deafness, suggesting a role for TRMU in the development of this disorder. Multiple isoforms of TRMU exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of TRMU of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of TRMU of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of TRMU of human origin |
| Entrez Gene | 55687 |
|---|
| Application Notes | recommended for detection of TRMU of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
