| Product Name | UBPY Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-300 mapping at the N-terminus of UBPY of human origin |
| Modification Notes | The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. UBPY, also known as USP8 (ubiquitin carboxyl-terminal hydrolase 8) or KIAA0055, is a 1,118 amino acid protein that contains one rhodanese domain and exists in a ternary complex with OTUB1 and GRAIL. Functioning as a hydrolase, UBPY catalyzes the removal of ubiquitin from ubiquitin-conjugated proteins and plays an important role in protein turnover, cellular proliferation and T-cell anergy. The gene encoding UBPY maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of UBPY of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of UBPY of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of UBPY of human origin |
| Entrez Gene | 9101 |
|---|
| Application Notes | recommended for detection of UBPY of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
