Application
Western blot analysis of ANKTM1 expression in non-transfected: (A) and human ANKTM1 transfected: (B) 293 whole cell lysates.| Product Name | ANKTM1 Antibody (H-155) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPC subtypes mediate store-operated Ca2+ entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphospate production and other Ca2+ mobilizing agents. TRP ion channels influence calcium-depletion induced calcium influx processes in response to chemo-, mechano- and osmoregulatory events. ANKTM1, also designated TRPA1, plays a role in both nociceptor and hair cell transduction. Activation of ANKTM1 occurs by perception of noxious cold (< 17 degrees Celsius), and pungent natural compounds, such as garlic, cinnamon oil and mustard oil. Inhibition of ANKTM1 impairs hair cell mechanotransduction. Blocking ANKTM1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ANKTM1 of mouse, rat and human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 965-1119 mapping at the C-terminus of ANKTM1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 965-1119 mapping at the C-terminus of ANKTM1 of human origin |
| Entrez Gene | 8989 |
|---|
Application
Western blot analysis of ANKTM1 expression in non-transfected: (A) and human ANKTM1 transfected: (B) 293 whole cell lysates.| Application Notes | recommended for detection of ANKTM1 of mouse, rat and human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
