Application
Western blot analysis of ING4 expression in non-transfected: (A) and human ING4 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of ING4 expression in non-transfected: (A) and mouse ING4 transfected: (B) 293T whole cell lysates.| Product Name | ING4 Antibody (H-40) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 41-80 mapping near the N-terminus of ING4 of human origin |
| Modification Notes | Inhibitor of growth protein (ING) family of nuclear proteins, also designated ING tumor suppressor proteins, inhibit tumor progression by modulating the transcriptional outputs of signaling pathways, which in turn regulates cell proliferation. Members of this family include ING1, ING2, ING3, ING4 and INGX. ING4 localizes to the nucleus and may inhibit tumor progression by adjusting the transcriptional output of signaling pathways which regulate cell proliferation. When complexed with RELA, ING4 can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes. ING4 interacts with HIF prolyl hydroxylase 2 (EGLN1), which represses the activity of hypoxia inducible factor (HIF). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ING4 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 41-80 mapping near the N-terminus of ING4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 41-80 mapping near the N-terminus of ING4 of human origin |
| Entrez Gene | 51147 |
|---|
Application
Western blot analysis of ING4 expression in non-transfected: (A) and human ING4 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of ING4 expression in non-transfected: (A) and mouse ING4 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of ING4 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
