| Product Name | GM3 Synthase Antibody (H-125) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 11-135 mapping near the N-terminus of GM3 Synthase of human origin |
| Modification Notes | GM3 Synthase, also known as Sialyltransferase 9 or ST3Gal V, is a Golgi type II transmembrane glycosyltransferase predominantly expressed in brain and placenta. It belongs to the glycosyltransferase family 29 and is involved in the biosynthesis of complex gangliosides. In particular, GM3 Synthase catalyzes the transfer of å sialic acid to the terminal galactose of lactosylceramide to form the ganglioside GM3. GM3 is the simplest ganglioside and it participates in cell differentiation, signal transduction, and modulation of cell proliferation. The synthesis of GM3 by GM3 Synthase is the first major step in the formation of almost all other gangliosides. For this reason, GM3 Synthase acts as a key regulatory enzyme in the biosynthesis of gangliosides. A mutation in the gene encoding GM3 Synthase can lead to the inability to synthesize å- and ∫-series gangliosides and may result in Amish infantile epilepsy syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of GM3 Synthase of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 11-135 mapping near the N-terminus of GM3 Synthase of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 11-135 mapping near the N-terminus of GM3 Synthase of human origin |
| Entrez Gene | 8869 |
|---|
| Application Notes | recommended for detection of GM3 Synthase of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
