| Product Name | cylindromatosis 1 Antibody (H-419) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Familial cylindromatosis is an autosomal dominant genetic predisposition to multiple benign neoplasms of the skin known as cylindromas. These cylindromas may become infected, resulting in disfigurement and discomfort. In severe cases, ulcerated cylindromas are only treatable by reconstructive surgery with skin grafts. The human CYLD gene on chromosome 16q12.1 encodes the protein cylindromatosis 1. Mutations in this gene are responsible for familial cylindromatosis. The cylindromatosis 1 protein contains three cytoskeletal-associated protein-glycineconserved (CAP-GLY) domains and may function to coordinate the attachment of organelles to microtubules. Cylindromatosis 1 is expressed in brain, gonads, skeletal muscle, spleen, liver, heart, lung and leukocytes. Somatic mutations of the CYLD gene appear to play a role in the oncogenesis of tumors with cylindromatous features. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of cylindromatosis 1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against the C-terminal 419 amino acids of cylindromatosis 1 of human origin |
|---|---|
| Tissue Specificity | raised against the C-terminal 419 amino acids of cylindromatosis 1 of human origin |
| Entrez Gene | 1540 |
|---|
| Application Notes | recommended for detection of cylindromatosis 1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
