Application
Western blot analysis of ERRα expression in non-transfected: (A) and human ERRα transfected: (B) 293T whole cell lysates.| Product Name | ERRα Antibody (H-80) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Estrogen related receptor alpha (ERRå) is a nuclear receptor in the superfamily of ligand-regulated transcription factors and is a member of the NR3B orphan nuclear receptor subgroup (consisting of å, ∫ and ©). ERRå plays a role in modulating the estrogen signaling pathway. In addition, the expression of ERRå has been shown to increase during fasting and cold exposure. ERRå may be important for regulating mitochondrial biogenesis and oxidative metabolism by acting directly on genes necessary for mitochondrial function. Mice lacking ERRå are unable to maintain their body temperature in the cold. ERRå may also be involved in the maintenance and formation of cartilage. This information could be useful in finding therapeutic agents for a variety of diseases affecting the joints. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAGSChIP |
| recommended for detection of ERRα of mouse, rat and human origin by WB, IP, IF and ELISAWB:1:100~1:200 IF:1:20~1:100 ELISA:1:1000~1:5000 IP:1:20~1:100 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 81-160 mapping near the N-terminus of ERR&alpha of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 81-160 mapping near the N-terminus of ERRα of human origin |
| Entrez Gene | 2101 |
|---|
Application
Western blot analysis of ERRα expression in non-transfected: (A) and human ERRα transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of ERRα of mouse, rat and human origin by WB, IP, IF and ELISAWB:1:100~1:200 IF:1:20~1:100 ELISA:1:1000~1:5000 IP:1:20~1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
