| Product Name | FucT-IV Antibody (H-88) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Fucosyltransferases (FucTs) catalyze the covalent association of fucose to different positional linkages on sugar acceptor molecules. The carbohydrate moieties that are generated are covalently attached to cell surfaces and are necessary to ensure a surface contour that satisfies a variety of physiological roles. FucT-IV (a 1,3-fucosyltransferase IV), also known as FUT4, FCT3A or ELFT, is a 405 amino acid single-pass type II membrane protein that localizes to golgi stacks. During embryogenesis, FucT-IV is highly expressed in skin, liver, kidney, muscle and small intestine where it functions to catalyze the glycosidic attachment of a-fucose to various molecules, such as N-acetyllactosamines. Via its catalytic activity, FucT-IV participates in the synthesis of carbohydrate molecules like the cell-adhesion antigen CD15 (also known as Lewis X), thereby playing a roll in cell cycle events such as apoptosis and cell-cell binding. Overexpression of FucT-IV is implicated in epithelial cancers, suggesting a possible role for FucT-IV in carcinogenesis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FucT-IV of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 286-373 mapping within an internal region of FucT-IV of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 286-373 mapping within an internal region of FucT-IV of human origin |
| Entrez Gene | 2526 |
|---|
| Application Notes | recommended for detection of FucT-IV of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
