Reg IV is part of the regenerating gene family within the C-type lectin superfamily. This family is involved in liver, pancreatic, gastric and intestinal cell proliferation and differentiation. Reg IV is a 158-amino acid secretory protein implicated in cell regeneration and/or survival with a definite growth stimulating effect on pancreatic beta cells. It is highly expressed in colorectal, gastric, prostate and other types of cancer. Reg IV-positive tumor cells display different phenotypes including mucus-secreting, enterocyte-like, and undifferentiated.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of Reg IV isoforms 1, 2 and 3 of mouse, human and, to a lesser extent, rat origin by WB, IP, IF and ELISA also reactive with additional species, including canine and porcine
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 23-62 mapping near the N-terminus of Reg IV of human origin
Tissue Specificity
epitope corresponding to amino acids 23-62 mapping near the N-terminus of Reg IV of human origin
Western blot analysis of Reg IV expression in mouse liver tissue extract.
Application Notes
recommended for detection of Reg IV isoforms 1, 2 and 3 of mouse, human and, to a lesser extent, rat origin by WB, IP, IF and ELISA also reactive with additional species, including canine and porcine
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.