Application
Western blot analysis of FKBP8 expression in non-transfected: (A) and mouse FKBP8 transfected: (B) 293T whole cell lysates.| Product Name | FKBP8 Antibody (H-220) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | FKBP8 (FKBPr38, FK506 binding protein 8) is an immunophilin family member lacking PPIase/arotamase activity that influences immunoregulation, protein folding and trafficking in neurons associated with memory function. The FKBPr38 form derives from a truncated ORF. Presenilin 1 and 2 form molecular complexes with—and promote degradation of—FKBPr38, and Bcl-2, and sequester these proteins in ER/Golgi, thereby inhibiting FKBPr38-mediated, ©-secretase-independent, mitochondrial targeting of Bcl-2. FKBP8 present in the central nervous system can antagonize hedgehog (HH) signaling, where HH is critical for patterning and growth of many tissues in the developing embryo. Mouse FKBPr38 mRNA is present in neurons and glial cells and appears more pronounced in neurons associated with the hippocampal formation in adult mouse brains. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FKBP8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 136-355 mapping at the C-terminus of FKBP8 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 136-355 mapping at the C-terminus of FKBP8 of human origin |
| Entrez Gene | 23770 |
|---|
Application
Western blot analysis of FKBP8 expression in non-transfected: (A) and mouse FKBP8 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of FKBP8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
