| Product Name | DSC2 Antibody (H-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Desmogleins are type I membrane proteins that are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. Desmogleins belong to the cadherin family and consist of dsg1, dsg2, dsg3 and dsg4. The desmosomal cadherin desmocollins DSC1 and DSC3 are also type I membrane proteins that may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms. Alternative splicing gives rise to isoforms A and B of DSC1 and DSC3, which differ in their C-termini. DSC2 exhibits homophilic interactions in solution, and forms heterophilic interactions with dsg2. DSC2 and DSC1 are present at high levels in the suprabasal skin layers. DSC2 protein is predominantly localized to specialized adhesion junctions between the cortex and the medulla. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Desmocollin 2A and 2B of human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 638-687 mapping within an N-terminal extracellular domain of DSC2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 638-687 mapping within an N-terminal extracellular domain of DSC2 of human origin |
| Entrez Gene | 1824 |
|---|
| Application Notes | recommended for detection of Desmocollin 2A and 2B of human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
