Application
Western blot analysis of ADAMTS-16 expression in non-transfected: (A) and human ADAMTS-16 transfected: (B) 293T whole cell lysates and mouse brain tissue extract (C).| Product Name | ADAMTS-16 Antibody (H-75) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | ADAMTS (a disintegrin and metalloproteinase domain with Thrombopondin 1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of thrombospondin 1 (TSP 1) motifs. Structurally, ADAMTS-16 most closely resembles ADAMTS-18. ADAMTS-16 is expressed predominantly in fetal lung and kidney tissues, as well as in adult brain tissue. ADAMTS-16 may play a role in cartilage aggrecan loss in osteoarthritis (OA), a disease of the joints. This role is suggested by a significant upregulation of ADAMTS-16 in OA synovium and cartilage. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ADAMTS-16 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 986-1060 mapping near the C-terminus of ADAMTS-16 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 986-1060 mapping near the C-terminus of ADAMTS-16 of human origin |
| Entrez Gene | 170690 |
|---|
Application
Western blot analysis of ADAMTS-16 expression in non-transfected: (A) and human ADAMTS-16 transfected: (B) 293T whole cell lysates and mouse brain tissue extract (C).| Application Notes | recommended for detection of ADAMTS-16 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
