| Product Name | CPSF3 Antibody (H-145) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | 3' ends of eukaryotic mRNAs can undergo processing events that include endonucleolytic cleavage and polyadenylation. Cleavage and polyadenylation specificity factor (CPSF) mediates 3' cleavage of the transcript and subsequent polyadenylation (2,3). CPSF contains four subunits and localizes to the nucleoplasm where it recognizes the AAUAAA signal in pre-mRNA and interacts with other proteins to facilitate RNA cleavage and poly(A) synthesis (1,4,5). The human CPSF3 gene maps to chromosome 2p25.1 and encodes the second shortest subunit of cleavage and polyadenylation specificity factor (6). U1 snRNP-A protein (U1A) interacts with and affects the activity of CPSF by stabilizing the interaction of CPSF with the AAUAAA-containing RNAs to increase the efficiency of polyadenylation (7). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CPSF3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 418-562 mapping within an internal region of CPSF3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 418-562 mapping within an internal region of CPSF3 of human origin |
| Entrez Gene | 51692 |
|---|
| Application Notes | recommended for detection of CPSF3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
