Application
Western blot analysis of MATE2 expression in KNRK whole cell lysate.| Product Name | MATE2 Antibody (L-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Transporters are expressed in a wide variety of tissues where they perform the critical function of enabling anionic and cationic chemicals of exogenous and endogenous origin to cross otherwise impermeable cell membranes. The multidrug and toxin extrusion (MATE) transporters mediate cellular efflux of a variety of organic cations, including many drugs. The MATE family of transporters is involved in excretion of toxic electrolytes through urine and bile. The MATE family share homology with the bacterial MATE protein family responsible for drug resistance. MATE2 (multidrug and toxin extrusion 2), also known as MATE2K, MATE2-B, MATE2-K or SLC47A2, is a 602 amino acid multi-pass membrane protein belonging to the MATE family that localizes to the brush border membrane of proximal tubules. Considered an H(+)-organic cation antiporter, MATE2 is responsible for the secretion of cationic drugs across the brush border membranes. MATE2 is expressed as 6 isoforms produced by alternative splicing event |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MATE2 isoforms 1, 3 and 4 of human origin by WB, IP, IF and ELISA non cross-reactive with MATE2- 2, MATE2-5 or MATE2-6 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within a C-terminal cytoplasmic domain of MATE2 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within a C-terminal cytoplasmic domain of MATE2 of human origin |
| Entrez Gene | 146802 |
|---|
Application
Western blot analysis of MATE2 expression in KNRK whole cell lysate.| Application Notes | recommended for detection of MATE2 isoforms 1, 3 and 4 of human origin by WB, IP, IF and ELISA non cross-reactive with MATE2- 2, MATE2-5 or MATE2-6 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
