| Product Name | PlGF Antibody (H-90) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis (1,2). Several growth factors with angiogenic activity have been described (3). These include fibroblast growth factor (FGF), platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). Like VEGF, several PlGF variants have been shown to arise from alternative mRNA splicings (4,5). Evidence has suggested VEGF to be an obligatory component in PlGF signaling (5,6). While VEGF homodimers and VEGF/PlGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PlGF homodimers are effectual only at extremely high concentrations (6). Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PlGF (6). VEGF and PlGF share a common receptor, Flt-1, and may also activate Flk-1/KDR (5,7) |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PIGF isoforms 1, 2 and 3 of human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 51-100 mapping within an internal region of PlGF isoform 1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 51-100 mapping within an internal region of PlGF isoform 1 of human origin |
| Entrez Gene | 5228 |
|---|
| Application Notes | recommended for detection of PIGF isoforms 1, 2 and 3 of human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
