Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human thyroid gland tissue showing cytoplasmic staining of glandular cells.Application
Western blot analysis of Inhibin β-A expression in non-transfected 293T: (A), mouse Inhibin β-A transfected 293T: (B) and A549 (C) whole cell lysates.| Product Name | Inhibin β-A Antibody (H-120) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The TGF∫ superfamily is composed of numerous growth and differentiation factors, including transforming growth factor ∫ (TGF∫) 1, 2 and 3; growth/differentiation factor (GDF) 1 through 8; Mullerian inhibiting substance (MIS); bone morphogenic protein (BMP) 2 through 8; glial cell line-derived neurotrophic factor (GDNF); inhibins (å, ∫-A, ∫-B and ∫-C), Lefty and Nodal. Members of the TGF∫ superfamily are involved in embryonic development and adult tissue homeostasis. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins and activins are involved in regulating a number of functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth depending on their subunit composition. Activins oppose the funtions of inhibins. Inhibins are predominantly expressed in liver, uterus and ovary tissue. Inhibin A, a dimer of å and ∫-A, and inhibin B, a dimer of å and ∫-B, have been shown to inhibit the secretion of follicle stimulating hormone. Inhibin ∫-C forms a homodimer and its expression is predominant in adult liver. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of precursor and mature Inhibin &beta-A, and to a lesser extent, Inhibin &beta-B of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 307-426 mapping at the C-terminus of Inhibin &beta -A of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 307-426 mapping at the C-terminus of Inhibin β-A of human origin |
| Entrez Gene | 3624 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human thyroid gland tissue showing cytoplasmic staining of glandular cells.
Application
Western blot analysis of Inhibin β-A expression in non-transfected 293T: (A), mouse Inhibin β-A transfected 293T: (B) and A549 (C) whole cell lysates.| Application Notes | recommended for detection of precursor and mature Inhibin &beta-A, and to a lesser extent, Inhibin &beta-B of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
