Application
Western blot analysis of ADAR2 expression in non-transfected: (A) and human ADAR2 transfected: (B) 293T whole cell lysates.| Product Name | ADAR2 Antibody (H-90) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | ADAR2, also designated adenosine deaminase, RNA-specific (RED1), RNA-editing enzyme 1, DRABA2, DRADA2, ADAR2a-L1, ADAR2a-L2 and ADAR2a-L3, mediates RNA editing by destabilizing RNA through deamination of adenosine to inosine. ADAR2 is responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. It can modify its own pre-mRNA and generate new splice sites. Translocation of endogenous ADAR2 from the nucleolus to the nucleoplasm results in increased editing of endogenous ADAR2 substrates. Alternative splicing of this gene results in several transcript variants that may influence RNA editing. RNA editing involves the deamination of adenosines at specific sites, the result of which can be a change in the amino acid sequence of the protein so that it differs from that predicted by the sequence of the DNA. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of all ADAR2 isoforms of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 281-370 mapping within an internal region of ADAR2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 281-370 mapping within an internal region of ADAR2 of human origin |
| Entrez Gene | 104 |
|---|
Application
Western blot analysis of ADAR2 expression in non-transfected: (A) and human ADAR2 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of all ADAR2 isoforms of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
