| Product Name | p-NFATc1 Antibody (Ser 257) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The NFAT (nuclear factor of activated T cells) family of transcription factors include the cytoplasmic NFAT transcription factors (NFATc1, NFATc2, NFATc3, NFATc4 and NFATc5) and nuclear NFAT (NFATn). Although primary cytoplasmic proteins, the nuclear translocation and transcriptional activity of the NF-ATc family is essential to developmental, differentiation, and adaptation processes. NFATc1 is present in uninduced cells and translocates to the nucleus upon calcium mobilization. The phosphatase calcineurin promotes nuclear accumulation of NF-ATc. PKA causes phosphorylation and cytoplasmic accumulation of NF-ATc1 in direct opposition to calcineurin by phosphorylating Ser-245, Ser-269, and Ser-294 in the conserved serine-proline repeat domain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Ser 257 phosphorylated NFATc1 SRR-2/NLS domain of human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to phosphorylated Ser 257 of NFATc1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to phosphorylated Ser 257 of NFATc1 of human origin |
| Entrez Gene | 4772 |
|---|
| Application Notes | recommended for detection of Ser 257 phosphorylated NFATc1 SRR-2/NLS domain of human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
