| Product Name | p-FGFR-3 Antibody (Tyr 724) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-3 maps to chromosome 4p16 and is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR-3 are associated with several diseases, including Crouzon syndrome, achondroplasia, thanatophoric dysplasia, craniosynostosis adelaide type and hypochondroplasia. Mutations in FGFR-3 are also a cause of some bladder and cervical cancers. Amino acid substitutions within the tyrosine kinase domain activation loop of FGFR-3 result in autophosphorylation of tyrosine residues in the intracellular domain. Phosphorylation at residue Tyr 724 abolishes all FGFR-3 tyrosine phosphorylation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Tyr 724 phosphorylated FGFR-3 of mouse, rat and human origin by WB, IF and ELISA may cross-react with correspondingly phosphorylated FGFR-1 and FGFR-2 also reactive with additional species, including equine, canine, bovine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to phosphorylated Tyr 724 of FGFR-3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to phosphorylated Tyr 724 of FGFR-3 of human origin |
| Entrez Gene | 2261 |
|---|
| Application Notes | recommended for detection of Tyr 724 phosphorylated FGFR-3 of mouse, rat and human origin by WB, IF and ELISA may cross-react with correspondingly phosphorylated FGFR-1 and FGFR-2 also reactive with additional species, including equine, canine, bovine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
