Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human bone marrow tissue showing cytoplasmic staining of megakaryocytes (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Western blot analysis of Integrin αIIb expression in human PBL whole cell lysate.Application
Western blot analysis of Integrin αIIb expression in human platelet whole cell lysate.Application
Western blot analysis of Integrin αIIb expression in human platelets (A), MEG-01 (B) and HEL 92.1.7 (C) whole cell lysates.| Product Name | Integrin αIIb Antibody (H-160) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Integrins are heterodimers composed of noncovalently associated transmembrane å and ∫ subunits. The 16 å and 8 ∫ subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of heavy and light chains of Integrin &alphaIIb of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 847-1006 of Integrin &alpha IIb of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 847-1006 of Integrin αIIb of human origin |
| Entrez Gene | 3674 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human bone marrow tissue showing cytoplasmic staining of megakaryocytes (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Western blot analysis of Integrin αIIb expression in human PBL whole cell lysate.
Application
Western blot analysis of Integrin αIIb expression in human platelet whole cell lysate.
Application
Western blot analysis of Integrin αIIb expression in human platelets (A), MEG-01 (B) and HEL 92.1.7 (C) whole cell lysates.| Application Notes | recommended for detection of heavy and light chains of Integrin &alphaIIb of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
