Application
Western blot analysis of ADAMTS-13 expression in human plasma whole cell lysate.Application
Western blot analysis of human recombinant ADAMTS-13 fusion protein.| Product Name | ADAMTS-13 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin 1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an amino-terminal propeptide do-main, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of Thrombospondin 1 (TSP-1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver. The human ADAMTS13 gene maps to chromosome 9q34.2 and encodes a 1,427-amino acid protein, known as von Willebrand factor-cleaving protease, that is expressed in the liver and placenta. ADAMTS-13 cleaves the peptide bond between Tyr 842 and Met 843 in monomeric subunits of von Willebrand factor. Human ADAMTS-13 protein can be expressed as multiple variants that share a common amino-terminal sequence. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ADAMTS-13 of mouse, rat and human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1128-1427 mapping at the C-terminus of ADAMTS-13 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1128-1427 mapping at the C-terminus of ADAMTS-13 of human origin |
| Entrez Gene | 11093 |
|---|
Application
Western blot analysis of ADAMTS-13 expression in human plasma whole cell lysate.
Application
Western blot analysis of human recombinant ADAMTS-13 fusion protein.| Application Notes | recommended for detection of ADAMTS-13 of mouse, rat and human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
