Application
Western blot analysis of FANCG expression in non-transfected: (A) and human FANCG transfected: (B) 293T whole cell lysates.Application
Western blot analysis of FANCG expression in non-transfected: (A) and human FANCG transfected: (B) 293T whole cell lysates.| Product Name | FANCG Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least 8 complementation groups (A-G) have been identified and 6 FA genes (for subtypes A, C, D2, E, F, and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. The cellular accumulation of FA proteins, including FANCA and FANCG, is subject to regulation by TNF-alpha signaling. Phosphorylation of FANC (Fanconi anemia complementation group) proteins is thought to be important for the function of the FA pathway. Phosphorylation of serine 7 in FANCG is functionally important in the FA pathway. FANCG is localized majorly in the nucleus and minorly in the cytoplasm, and is highly expressed in testis and thymus. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FANCG of mouse, rat and human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 323-622 mapping at the C-terminus of FANCG of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 323-622 mapping at the C-terminus of FANCG of human origin |
| Entrez Gene | 2189 |
|---|
Application
Western blot analysis of FANCG expression in non-transfected: (A) and human FANCG transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of FANCG expression in non-transfected: (A) and human FANCG transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of FANCG of mouse, rat and human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
