| Product Name | CYLD Antibody (d1-316) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-316 raised against amino acids 1-316 of CYLD of Drosophila origin |
| Modification Notes | Familial cylindromatosis is an autosomal dominant predisposition to tumours of skin appendages called cylindromas (1). Cylindromas are benign adnexal skin tumors caused by germline mutations in the CYLD gene (2), which maps to 16q12-13 (3). CYLD is a deubiquitinating enzyme that negatively regulates activation of NF˚B by specific TNF receptors (1) and is required for appropriate cellular homeostasis of skin appendages (1). Mutations in the CYLD gene are also involved in Brooke-Spiegler syndrome, an inherited disease characterized by neoplasms of the skin appendages such as cylindroma, trichoepithelioma, and spiradenoma (3,4). The Drosophila homolog of CYLD is referenced in Flybase as CG5603 (5). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CYLD of Drosophila origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-316 raised against amino acids 1-316 of CYLD of Drosophila origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-316 raised against amino acids 1-316 of CYLD of Drosophila origin |
| Application Notes | recommended for detection of CYLD of Drosophila origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
