| Product Name | Elastase-1 Antibody (H-122) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Elastase-1 is a serine protease that belongs to the elastase subfamily of the peptidase S1 family. It is secreted by the exocrine pancreas in all mammals but is transcriptionally silent in human pancreas due to mutations that inactivate its promoter and enhancer. Elastase-1 plays a role in the digestion of elastin, fibrin, hemoglobin and albumin and its activity can be inhibited by elafin. In humans, Elastase-1 is expressed only in skin keratinocytes and localizes to the basal cell layer of the epidermis where it may play a role in the detachment of cells from the basement membrane. Elastase-1 expressed in keratinocytes may be inhibited by SLPI (secretory leukocyte protease inhibitor) instead of elafin. In adddition, Elastase-1 may be a candidate for diffuse nonepidermolytic palmoplantar keratoderma (NEPPK), an autosomal dominant skin disease. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Elastase-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 62-183 mapping within an internal region of Elastase-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 62-183 mapping within an internal region of Elastase-1 of human origin |
| Entrez Gene | 1990 |
|---|
| Application Notes | recommended for detection of Elastase-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
