Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic and nuclear staining of glandular cells.Application
Western blot analysis of DOCK 8 expression in Raji whole cell lysate.| Product Name | DOCK 8 Antibody (H-159) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | DOCK 8 (dedicator of cytokinesis 8) is a 2,099 amino acid protein that contains one DHR-2 (CZH-2) domain and one DHR-1 (CZH-1) domain. One of several members of the DOCK family of cytokinesis-regulating proteins, DOCK 8 functions as a potential guanine nucleotide exchange factor (GEF) that may play a role in protein activation and is thought to influence Actin organization. Defects in the gene encoding DOCK 8 may be associated with the pathogenesis of autosomal dominant mental retardation, possibly due to errors in Actin-based cytoskeletal structure. Multiple isoforms of DOCK 8 exist due to alternative splicing events. The gene encoding DOCK 8 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of DOCK 8 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA non cross-reactive with other DOCK family members also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 119-277 mapping near the N-terminus of DOCK 8 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 119-277 mapping near the N-terminus of DOCK 8 of human origin |
| Entrez Gene | 81704 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic and nuclear staining of glandular cells.
Application
Western blot analysis of DOCK 8 expression in Raji whole cell lysate.| Application Notes | recommended for detection of DOCK 8 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA non cross-reactive with other DOCK family members also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
