| Modification Notes |
The human pancreas secretes three different isoforms of the inactive trypsinogen into the small intestine, namely cationic trypsinogen, anionic trypsinogen (the two major isoforms) and mesotrypsinogen (a minor isoform). In the small intestine, each isoform is cleaved by Enterokinase into its active form, Trypsin-1, Trypsin-2 and Trypsin-3, respectively. All Trypsins are members of the serine protease Trypsin family. The activated Trypsins go on to activate other protease zymogens and play a role in the autoactivation of trypsinogens, suggesting an important role for Trypsins in digestion. Trypsin X3, also known as TRYX3 or TRY1, is a 241 amino acid secreted protein that contains one peptidase S1 domain and functions to catalyze the cleavage of specific amino acid bonds. |